In-biorreactor ultrasonic monitoring of tissue mechanical properties

uantitative control of tissue processes in bioreactors is an open problem in tissue engineering, aimed at creating artificial tissues and organs. To standardize and optimize the process, it is necessary to control most of the parameters that may vary its effectiveness. We propose to monitor the changes that may suffer the matrix during the process using mechanical parameters. To ensure the viability of this protocol, a bioreactor has been designed. The proposed methodology consists of three elements: an (1) experimental setup based on ultrasound-tissue interactions monitored in real-time, a (2) computational model that simulates the ultrasound-tissue interactions, and a (3) model-based inverse problem to reconstruct the evolution of the relevant mechanical parameters.

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